7.3 Translation

Synthesis of the polypeptide involves a repeated cycle of events.

Disassembly of the components follows termination of translation.

Free ribosomes synthesize proteins for use primarily within the cell.

Bound ribosomes synthesize proteins primarily for secretion or for use in lysosomes.

Translation can occur immediately after transcription in prokaryotes due to the absence of a nuclear membrane.

The sequence and number of amino acids in the polypeptide is the primary structure.

The secondary structure is the formation of alpha helices and beta pleated sheets stabilized by hydrogen bonding.

The tertiary structure is the further folding of the polypeptide stabilized by interactions between R groups.

The quaternary structure exists in proteins with more than one polypeptide chain.

Examples of start and stop codons are not required.

Polar and non-polar amino acids are relevant to the bonds formed between R groups.

Quaternary structure may involve the binding of a prosthetic group to form a
conjugated protein.

The use of molecular visualization software to analyse the structure of eukaryotic ribosomes and a tRNA molecule.